Study record
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders (Baker et al., 2011)
Animal healthspan / mechanism study
○ Evidence tier 6 — Animal healthspan / mechanism study
Record verify: verified against primary source
| Design | Transgenic genetic-clearance study (mouse) |
| DOI | 10.1038/nature10600 |
| Citation status | doi verified via Crossref 2026-07-12 (Nature 2011;479(7372):232-236, Baker et al.) |
Identifiers: DOI verified; PMID not reported; trial registry id not applicable to this study type. Record-level verification and identifier-level status are separate: a record can be fully verified against its primary publication while an identifier that cannot apply to the study type — a trial registry ID for an animal study, for instance — is marked not applicable. No identifier is fabricated, and none is left in a “pending” state.
Five-qualifier claim
| Species / population | INK-ATTAC transgenic mice (BubR1 progeroid background). |
| Exposure, route, schedule | AP20187 inducer to trigger apoptosis in p16-expressing cells. |
| Comparator / duration | Vehicle-treated transgenic littermates; lifelong. |
| Endpoint / numeric result | Clearing p16-positive cells delayed onset of age-related changes in adipose tissue, skeletal muscle, and eye. |
| What it did NOT establish | Genetic tool in a progeroid model; not a drug and not a human result. |