Study record
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan (Baker et al., 2016)
Replicated animal lifespan study
○ Evidence tier 5 — Replicated animal lifespan study
Record
| Design | Transgenic genetic-clearance lifespan study (mouse) |
| DOI | 10.1038/nature16932 |
| Citation status | doi verified via Crossref 2026-07-12 (Nature 2016;530(7589):184-189, Baker et al.) |
Five-qualifier claim
| Species / population | INK-ATTAC transgenic wild-type mice, two genetic backgrounds. |
| Exposure, route, schedule | AP20187 twice weekly from ~1 year of age to clear p16-expressing cells. |
| Comparator / duration | Vehicle-treated transgenic controls; followed for lifespan. |
| Endpoint / numeric result | Lifelong clearance of p16-positive cells extended median lifespan in both sexes and delayed tumorigenesis and organ deterioration, without overt side effects. |
| What it did NOT establish | Median-lifespan extension via a genetic tool in mice; does not establish any human drug effect. |
Primary reference
https://www.nature.com/articles/nature16932
Exact identifier to be confirmed against the primary record before publication where flagged above.