Study record
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan (Baker et al., 2016)
Animal lifespan study
○ Evidence tier 5 — Animal lifespan study
Record verify: verified against primary source
| Design | Transgenic genetic-clearance lifespan study (mouse) |
| DOI | 10.1038/nature16932 |
| Citation status | doi verified via Crossref 2026-07-12 (Nature 2016;530(7589):184-189, Baker et al.) |
Identifiers: DOI verified; PMID not reported; trial registry id not applicable to this study type. Record-level verification and identifier-level status are separate: a record can be fully verified against its primary publication while an identifier that cannot apply to the study type — a trial registry ID for an animal study, for instance — is marked not applicable. No identifier is fabricated, and none is left in a “pending” state.
Five-qualifier claim
| Species / population | INK-ATTAC transgenic wild-type mice, two genetic backgrounds. |
| Exposure, route, schedule | AP20187 twice weekly from ~1 year of age to clear p16-expressing cells. |
| Comparator / duration | Vehicle-treated transgenic controls; followed for lifespan. |
| Endpoint / numeric result | Lifelong clearance of p16-positive cells extended median lifespan in both sexes and delayed tumorigenesis and organ deterioration, without overt side effects. |
| What it did NOT establish | Median-lifespan extension via a genetic tool in mice; does not establish any human drug effect. |