Study record
Clearance of senescent cells by ABT-263 rejuvenates aged tissue in mice (Chang et al., 2016)
Animal healthspan / mechanism study
○ Evidence tier 6 — Animal healthspan / mechanism study
Record verify: verified against primary source
| Design | Preclinical (mouse) senolytic clearance study |
| PMID | 26657143 |
| DOI | 10.1038/nm.4010 |
| Citation status | doi+pmid verified via Crossref 2026-07-12 (Nat Med 2016;22(1):78-83, Chang et al.; PMID 26657143) |
Identifiers: DOI verified; PMID verified; trial registry id not applicable to this study type. Record-level verification and identifier-level status are separate: a record can be fully verified against its primary publication while an identifier that cannot apply to the study type — a trial registry ID for an animal study, for instance — is marked not applicable. No identifier is fabricated, and none is left in a “pending” state.
Five-qualifier claim
| Species / population | Aged and irradiated mice. |
| Exposure, route, schedule | Oral ABT-263 (navitoclax), intermittent. |
| Comparator / duration | Vehicle-treated controls. |
| Endpoint / numeric result | Cleared senescent haematopoietic and muscle stem cells and rejuvenated aged/irradiated stem-cell function. |
| What it did NOT establish | Mouse tissue rejuvenation, not a lifespan or human outcome; systemic use limited by thrombocytopenia. |