Intervention
Quercetin
Mechanism, regulatory status, and an honest, tiered evidence map.
○ Human lifespan evidence: none (animal/preclinical or mechanism only)
What it is
Class: Flavonoid (senolytic combination component)
Also known as: flavonol quercetin
Relationship to senescence: A dietary flavonoid used as the flavonoid partner in the dasatinib+quercetin combination; on its own it is a comparatively weak senolytic and broadens the range of senescent cell types cleared when combined with dasatinib.
Regulatory status
Dietary supplement; not an approved drug and not approved as a senolytic. No established senolytic dose.
Mechanism
Affects Bcl-2-family, PI3K, and SERPINE-related survival nodes; studied almost exclusively in combination, not as a standalone human senolytic. See /dasatinib-quercetin.
Evidence — In vitro / combination
| Species / population | Cultured senescent cells; human pilots only as part of D+Q. |
| Exposure, route, schedule | Studied in combination with dasatinib; standalone senolytic dosing not established. |
| Comparator / duration | Combination vs single-agent in preclinical work. |
| Endpoint / numeric result | Broadens senescent-cell-type coverage of the combination. |
| What it did NOT establish | No standalone human senolytic evidence; no lifespan data. |
Negative or null findings
- Standalone quercetin has not been shown to clear senescent cells or affect aging outcomes in humans.